Bupropion (Wellbutrin SR, Zyban – Bupron XL) 300 mg tablet XL is the most widely used norepinephrine/dopamine-reuptake inhibitor (NDRI) for the treatment of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and smoking cessation aids.
Bupropion helps you stop smoking by reducing the withdrawal symptoms caused by smoking cessation. It can also be used for seasonal affective disorder, which is characterized by mood disorders during the autumn and/or winter months.
Drug = Bupropion
Strength = 300 mg
Manufacturer = Sun Pharma
Quantity per sleeve = 30 Tablet (for the price quoted)
How To Take Bupropion (Wellbutrin SR, Zyban – Bupron XL) 300 mg Tablet XL
Bupropion may be taken with or without food. Try to take Bupropion at the same time each day.
If you are taking the sustained-release, prolonged-release or extended-release type of tablet (usually labeled as “SR”, “XL” or “ER”), swallow it whole. Do not divide, chew or crush the tablet.
This medicine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
Take Bupropion exactly as directed by your doctor or according to the instructions on the label.
If you are taking Bupropion for smoking cessation, get a target date to stop smoking within 2 weeks of starting Bupropion.
Dosage of Bupropion (Wellbutrin SR, Zyban – Bupron XL) 300 mg Tablet XL
Smoking cessation: As modified-release preparation: Initial: 150 mg once daily for 6 days, then increase to 150 mg twice a day. Duration: 7-9 weeks. Maximum: 300/day.
Depression: Initial: 100 mg twice a day, up to 100 mg three times a day after 3 days if needed. Maximum: 150 mg three times a day. As a modified-release preparation: 150 mg once daily, increased to 150 mg twice a day after 3 days, then up to 200 mg twice a day after several weeks if needed. Maximum: 450 mg as a single dose.
Missed Bupropion (Wellbutrin SR, Zyban – Bupron XL) 300 mg Tablet XL
If you often forget to take your medicine, let your doctor and pharmacist know.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.
Do not double a dose under any circumstances.
Signs of overdose may include the following:
- Loss of consciousness
Seek medical help immediately.
People with the following medical conditions should not take Bupropion:
- Current or history of seizure disorder
- Anorexia nervosa
- CNS tumor
- History of bipolar disorder (when used as an aid in smoking cessation)
- Abrupt withdrawal of alcohol, benzodiazepines, barbiturates, antiepileptic drugs
- Severe hepatic cirrhosis.
- Concomitant admin or within 14 days of MAOIs withdrawal
Side Effects of Bupropion (Wellbutrin SR, Zyban – Bupron XL) 300 mg Tablet XL
Bupropion may have the following side effects:
- Dry mouth
- Abdominal pain
- Suicidal ideation
- Emotional lability
- Urinary frequency or retention
- Hot flushes
- Facial edema
- Gastric reflux
- Increased salivation
- Mouth ulcers
- Leg cramps
- Decreased libido
- Pulmonary embolism
- Gastrointestinal hemorrhage
- Intestinal perforation
- Stomach ulcer
- Muscle weakness
- Stevens-Johnson syndrome
- Increased intraocular pressure
- Abnormal ejaculation
Warnings of Bupropion (Wellbutrin SR, Zyban – Bupron XL) 300 mg Tablet XL
Do not use Bupropion in people with the following conditions:
- History of head trauma
- Tumor involving the central nervous system
- Undergoing abrupt withdrawal from alcohol, sleeping pills, medicines for epilepsy
- Eating disorders
Inform your doctor and pharmacist if you are taking any of these medicines:
- Monoamine oxidase inhibitors
Always notify the doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
This list does not include all medicines that may interact with Bupropion.
How Does It Work?
Bupropion acts with the neuronal uptake of norepinephrine and dopamine and a relatively poor inhibitor with a minimal effect on serotonin reuptake. It is assumed that the mechanism by which it assists in smoking cessation is mediated by its noradrenergic and/or dopaminergic behaviors.
Bupropion is used to treat the following conditions:
- Smoking cessation
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with bipolar disorders (in the treatment of depression)
- Recent history of heart attack or unstable heart disease
- Alcohol abuse
- History of head trauma
- Renal or mild to moderate hepatic impairment
- Avoid alcohol
- Store between 15-30°C.
- Store in a cool, dry place away from the reach of children.
- Do not use Bupropion that is expired or out of expiry date.