Description
Exemestane (Aromasin-Xtane) 25 mg tablet is an oral steroidal aromatase inhibitor used in women who have reached menopause or who have stopped the menstrual cycle to treat breast cancer. Aromatase is an enzyme that converts hormones to estrogen in the body’s adrenal glands. The aromatase inhibitors (AIs) are drugs that reduces estrogen levels by blocking the action of aromatase in the adrenal glands.
Drug = Exemestane
Strength = 25mg
Manufacturer = Natco
Quantity per sleeve = 30 Tabs (for the price quoted)
How To Take Exemestane (Aromasin-Xtane) 25 mg Tablet
Take it together with food or immediately after a meal. Try to take it at the same time each day.
Exemestane must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take Exemestane exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
Dosage of Exemestane (Aromasin-Xtane) 25 mg Tablet
Adjuvant therapy for postmenopausal women with hormone receptor positive early breast cancer: 25 mg once daily for 5 years of combined adjuvant hormonal therapy (following tamoxifen).
Advanced breast cancer in postmenopausal women: 25 mg once daily until evident tumor progression.
Missed Dose of Exemestane (Aromasin-Xtane) 25 mg Tablet
If you often forget to take your medicine, let your doctor and pharmacist know.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.
Do not double a dose under any circumstances.
Overdose
If you think you may have used Exemestane more than the usual dose, please seek medical help immediately.
Contraindications of Exemestane (Aromasin-Xtane) 25 mg Tablet
People with the following medical conditions should not take Exemestane:
- Premenopausal women
- Pregnancy
- Lactation
Side Effects of Exemestane (Aromasin-Xtane) 25 mg Tablet
Exemestane may have the following side effects:
- Depression
- Insomnia
- Headache
- Dizziness
- Hot flushes
- Abdominal pain
- Nausea
- Increased hepatic enzyme, blood bilirubin and blood alkaline phosphatase
- Increased sweating
- Joint and musculoskeletal pain
- Pain
- Fatigue
- Anorexia
- Carpal tunnel syndrome
- Vomiting
- Diarrhea
- Constipation
- Dyspepsia
- Alopecia
- Rash
- Fracture
- Osteoporosis
- Peripheral edema
Warnings of Exemestane (Aromasin-Xtane) 25 mg Tablet
Inform your doctor and pharmacist if you are taking any of these medicines:
- Phenytoin
- Carbamazepine
- Phenobarbital
- Rifampicin
- St. John’s wort
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
This list does not include all medicines that may interact with Exemestane.
How Does It Work?
Exemestane is a irreversible, selective aromatase inhibitor that functions as the false substrate of the enzyme and forms an intermediate that binds to its active site. Inactivation or inhibition will avoid the conversion of androgens into peripheral tissue estrogens, thus reducing circulating estrogens in postmenopausal women with estrogen-dependent growth-dependent breast cancers.
Uses
Exemestane is used to treat the following conditions:
- Adjuvant therapy for postmenopausal women with hormone receptor positive early breast cancer
- Advanced breast cancer in postmenopausal women
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Women with premenopausal endocrine status
- Osteoporosis
- Concomitant use with estrogen-containing products.
- Women with vitamin D deficiency
- Avoid alcohol
Storage Conditions
- Store at temperatures not exceeding 30°C.
- Store in a cool, dry place away from the reach of children.
- As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.
- Do not use Exemestane that is expired or out of expiry date.
