Description
Propranolol hydrochloride (Inderal-Provonal) 40mg tablet is a nonselective beta-adrenergic receptor antagonist that helps to keep the blood pressure under control.
It is also used to treat angina pectoris (chest pain), irregular heartbeat, and thickened heart muscles. It may also be used to prevent further heart attacks or reduce the risks of complications after a heart attack.
Drug = Propranolol hydrochloride
Strength = 40mg
Manufacturer = Intas
Quantity per sleeve = 100 Tabs (for the price quoted)
How To Take Propranolol hydrochloride (Inderal-Provonal) 40mg Tablet
Ask your doctor or pharmacist about whether you should take this medicine with or without food. Different preparations of this medicine may be taken differently. Try to take it at the same time each day.
This medicine is available as a tablet, capsule or as an oral solution.
If you are taking the extended-release (usually labeled as “ER”) capsule, swallow it whole. Do not divide, chew or crush the capsule.
Do not change from one brand or preparation of Propranolol to another unless instructed to do so by your doctor.
Propranolol must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor, as stopping it suddenly could worsen your condition.
Dosage of Propranolol hydrochloride (Inderal-Provonal) 40mg Tablet
Hypertension: As a conventional tab or oral solution: Initially, 40-80 mg twice a day, may be increased at weekly intervals according to response. Usual range:160-320 mg daily. Maximum: 640 mg/day. As extended-release cap: 80 mg once daily.
Angina pectoris: As a conventional tab or oral solution: Initially, 40 mg twice or three times a day, may be increased according to response. Usual range: 120-240 mg daily. As extended-release cap: 80mg once daily, may be increased to 160 mg once daily. Maximum: 320 mg.
Prophylaxis of migraine: As a conventional tab or oral solution: Initially, 40 mg twice or three times a day, may be increased according to response. Usual range: 80-160 mg daily. As extended-release cap: Initially, 80mg once daily, may be increased according to response. Usual effective dose: 160-240 mg once daily.
Essential tremor: As a conventional tab or oral solution: Initially, 40 mg twice or three times a day, may be increased according to response. Usual range: 80-160 mg daily. As extended-release cap: Initially, 80mg once daily, may be increased according to response. Usual effective dose: 160-240 mg once daily.
Cardiac arrhythmias: As a conventional tab or oral solution: 10-40 mg 3-4 times daily.
Myocardial infarction: As conventional tab or oral solution: Initiate within 5-21 days of MI, 40 mg 4 times daily for 2-3 days, followed by 80 mg twice a day.
Pheochromocytoma: As a conventional tab or oral solution: In combination with an α-blocker: 60 mg daily for 3 days before the surgery. If the tumor is unsuitable for surgery, 30 mg/day in divided doses.
Hypertrophic cardiomyopathy: As a conventional tab or oral solution:10-40 mg 3-4 times daily. As extended-release cap: 80-160 mg once daily.
Hyperthyroidism: As a conventional tab or oral solution: 10-40 mg 3-4 times daily. As extended release cap: 80 mg once daily, may be increased to 160 mg daily. Maximum: 240 mg/day.
Anxiety: As a conventional tab or oral solution: 40 mg daily, may be increased if necessary to 40 mg twice or three times a day. As extended release cap: 80 mg once daily.
Portal hypertension: As a conventional tab or oral solution: Initially, 40 mg twice a day, may be increased to 80 mg twice a day depending on heart rate response. As extended release cap: 80 mg once daily, may be increased to 160 mg once daily. Maximum: 320 mg once daily.
Missed Dose of Propranolol hydrochloride (Inderal-Provonal) 40mg Tablet
If you often forget to take your medicine, let your doctor and pharmacist know.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.
Do not double a dose under any circumstances.
Overdose of Propranolol hydrochloride (Inderal-Provonal) 40mg Tablet
Signs of overdose may include the following:
- Bradycardia
- Hypotension
- Acute cardiac insufficiency
- Bronchospasm
Seek medical help immediately.
Contraindications
People with the following medical conditions should not take Propranolol:
- Hypersensitivity
- History of bronchial asthma or bronchospasm
- Bradycardia
- Cardiogenic shock
- Hypotension
- Metabolic acidosis
- After prolonged fasting
- Severe peripheral arterial circulatory disturbances
- 2nd or 3rd degree heart block
- Sick sinus syndrome
- Untreated pheochromocytoma
- Uncontrolled heart failure
- Prinzmetal’s angina
- Patients prone to hypoglycemia
Side Effects
Propranolol may have the following side effects:
- Fatigue and/or lassitude
- Bradycardia
- Cold extremities
- Raynaud’s phenomenon
- Sleep disturbances
- Nightmare
Warnings
Do not use Propranolol in people with the following conditions:
- Asthma
- Bronchospasm
- Slow heartbeat
- Shock caused by a heart problem
- Heart block (2nd or 3rd degree)
- Uncontrolled heart failure
- Abnormal heart rhythm
- Low blood pressure
- Increased acidity of the blood
- Poor blood circulation due to a blood vessel disorder
- Prinzmetal’s angina
- Untreated pheochromocytoma
Inform your doctor and pharmacist if you are taking any of these medicines:
- Reserpine
- Clonidine
- Nifedipine
- Verapamil
- Lidocaine
- Insulin
- Quinidine
- Amiodarone
- Propafenone
- Warfarin
- Chlorpromazine
- Ibuprofen
- Indometacin
- Ergotamine
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
This list does not include all medicines that may interact with Propranolol.
How Does It Work?
Propranolol works by competitively blocking beta1 and beta2-receptors resulting in decreased heart rate, myocardial contractility, blood pressure, and myocardial oxygen demand. It contains negative inotropic effects and membrane-stabilizing activities but does not possess intrinsic sympathomimetic activities.
Uses
Propranolol is used to treat the following conditions:
- Hypertension
- Angina pectoris
- Prophylaxis of migraine
- Essential tremor
- Cardiac arrhythmias
- Myocardial infarction
- Pheochromocytoma
- Hypertrophic cardiomyopathy
- Hyperthyroidism
- Anxiety
- Portal hypertension
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Poor cardiac reserve
- 1st-degree heart block
- History of anaphylactic reaction to allergens
- Decompensated cirrhosis
- Portal hypertension
- May aggravate less severe peripheral arterial circulatory disturbances
- Block/Modify signs and symptoms of hypoglycemia
- Mask signs of thyrotoxicosis
- Reduce heart rate
- Avoid abrupt withdrawal in patients with ischemic heart disease
- Patients on hemodialysis
- Concomitant antidiabetic therapy
- Chronic liver disease
- Withdraw gradually
- Hepatic or renal impairment
- Pregnancy
- Lactation
- Avoid alcohol
Storage Conditions
- Store at temperatures not exceeding 30°C. Protect from light and moisture.
- Store in a cool, dry place away from the reach of children.
- Do not use Propranolol that is expired or out of expiry date.
