Sildenafil (Silagra 50) 50 mg tablet is an inhibitor of phosphodiesterase-5 (PDE5) enzyme, which is primarily used to treat erectile dysfunction and pulmonary hypertension.
Sildenafil is a specific and effective inhibitor of cyclic guanosine monophosphate (cGMP) type 5 (PDE5) phosphodiesterase enzyme in the corpus cavernosum that induces pulmonary vascular smooth muscle cell relaxation. It replenishes reduced erectile capacity by raising blood flow to the penis; Sildenafil also requires sexual stimulation to achieve its pharmacological effects.
Drug = Sildenafil
Strength = 50 mg
Manufacturer = Cipla Limited
Quantity per sleeve = 4 Tablet (for the price quoted)
How To Take Sildenafil (Silagra 50) 50 mg Tablet
This medicine may be taken with or without food. The tablet must be swallowed whole with a glassful of water.
Try to take it at the same time each day. It must be taken regularly for it to be effective.
Take exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor. Do not stop taking it unless instructed by the doctor.
Dosage of Sildenafil (Silagra 50) 50 mg Tablet
Adult: Erectile dysfunction: 50 mg approximately 1 hour before sexual intercourse. Maximum dose of 100 mg/day.
Pulmonary arterial hypertension: 5 mg or 20 mg three times a day.
Missed Dose of Sildenafil (Silagra 50) 50 mg Tablet
If you often forget to take your medicine, let your doctor and pharmacist know.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your usual dosing schedule.
Do not double a dose under any circumstances.
If you think you may have used Sildenafil more than the usual dose, please seek medical help immediately.
Symptoms of overdose may include the following:
- Prolonged erection
People with the following medical conditions should not take Sildenafil:
- Unstable angina
- Cardiac failure
- Loss of vision in 1 eye because of non-arteritic anterior ischemic optic neuropathy (NAION)
- Hypotension (BP <90/50 mmHg)
- Recent history of stroke or myocardial infarction
- Known hereditary degenerative retinal disorders
- Severe hepatic impairment
Sildenafil may have the following side effects:
- Blurred vision
- Eye irritation, pain and redness
- Nasal congestion
- Skin rashes
- Limb/back pain
- Facial edema
- Fluid retention
- Urinary tract infection
- Sudden decrease or loss of hearing
- Urinary frequency or incontinence
- Cerebrovascular hemorrhage
- Transient ischemic attack
- Hypersensitivity reactions
- NAION causing permanent loss of vision
- Retinal hemorrhage
- Myocardial infarction
- Unstable angina
Do not take Sildenafil with the following medicines:
- HIV-protease inhibitors
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
This list does not include all medicines that may interact with Sildenafil.
How Does It Work?
Sildenafil is a potent and selective inhibitor of the specific phosphodiesterase type 5 (PDE5) cyclic guanosine monophosphate (cGMP) enzyme in the corpus cavernosum, resulting in the relaxation of pulmonary vascular smooth muscle cells. By increasing the blood flow to the penis, it restores damaged erectile function; thus, sexual stimulation is needed for Sildenafil to achieve its pharmacological effects.
Sildenafil is used to treat the following conditions:
- Erectile dysfunction
- Pulmonary arterial hypertension
Special Precautions and Connected Warnings
Take special precautions if you have the following conditions:
- Patient with anatomical deformation of the penis
- Hematological disorders that may predispose to priapism
- Not indicated for pulmonary hypertension secondary to sickle-cell disease
- Mild to moderate hepatic and severe renal impairment
- Children (chronic use)
- Store between 15-30°C.
- Store in a cool, dry place away from the reach of children.
- Do not use Sildenafil that is expired or out of date.